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Clonal evolution of medulloblastoma BTICs (brain tumor initiating cells) in response to therapy: Discovering the refractory BTIC population through genes regulating stem cell self-renewal

Clonal evolution of medulloblastoma BTICs (brain tumor initiating cells) in response to therapy: Discovering the refractory BTIC population through genes regulating stem cell self-renewal
髓母细胞瘤 BTIC(脑肿瘤起始细胞)响应治疗的克隆进化:通过调节干细胞自我更新的基因发现难治性 BTIC 群体
批准号:
279084
负责人:
Singh Sheila K
金额:
$40.36万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-03-01 至 2018-03-01

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中文摘要
翻译
脑瘤是儿童癌症死亡的主要原因,因为它们具有高度侵袭性,而且往往是无法治愈的。髓母细胞瘤是儿童最常见的恶性脑肿瘤,长期以来一直被认为与干细胞有关。这条狗
英文摘要
Brain tumors represent the leading cause of childhood cancer mortality, due to their highly aggressive and often incurable nature. For medulloblastoma, the most frequent malignant pediatric brain tumor, a stem cell origin has long been implicated. The cur
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Targeting BACE1 for the prevention and treatment of Brain metastases
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Dynamic metabolic reprogramming drives myc-amplified medulloblastoma recurrence
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Wnt activation as a therapeutic strategy for treatment-refractory childhood medulloblastoma
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海外基金