A high resolution, supersonically cooled 'Cold-EI' mass spectrometer

合成化学家每天都在制造新的分子，UVic的合成化学家的目标范围从产生新的癌症治疗方法，到制备用于医疗诊断的智能材料，再到合成新型催化剂以推动节能的工业化学过程。所有这些不同的目标都需要合成化学家，这些都需要快速分析以确定它们的身份。质谱法是一项不可或缺的技术，因为它能够非常快速（几秒钟）以高精度确定质量和元素组成（从而确定其身份）。这些信息可以让化学家确认他们已经制造出了他们想要的化合物，他们可以继续下一步和/或公布数据，作为该化合物的身份和纯度的证据的一部分。维多利亚大学化学系有几个这样的仪器，但负责分析非极性分子的仪器最近失败了，使我们完全缺乏一个关键的工具，并在该系一半的研究小组的工作流程中造成了严重的瓶颈。在这一损失中还有一线希望，那就是质谱技术在最近的过去取得了革命性的进步。今天的机器更小，更多功能和更强大，我们利用我们的联系和我们自己在化学合成方面的记录，获得了一个巨大的折扣（bbb50 %），这将是加拿大第一个这样的仪器。所要求的资金将使我们能够更换我们的关键基础设施，同时也使我们能够开辟以前受旧技术限制的新领域。

Synthetic chemists make new molecules every day, and the goals of synthetic chemists at UVic range from the generation of new cancer therapeutics, to the preparation of smart materials for medical diagnostics, to the synthesis of novel catalysts to drive energy efficient industrial chemical processes. All of these diverse goals require that the synthetic chemist and these require rapid analysis to determine their identity. Mass spectrometry is an indispensable technique for this purpose, because it is capable of very quickly (seconds) determining the mass and elemental composition (and thereby its identity) with high accuracy. That information allows the chemist to confirm that they've made the compound they intended to, and they can move on to the next step and/or publish the data as part of their evidence for that compound's identity and purity. The Department of Chemistry at the University of Victoria has several such instruments, but the one responsible for analyzing non-polar molecules recently failed, leaving us entirely lacking a critical tool and creating a serious bottleneck in the workflow of half of the Department's research groups. A silver lining in this loss is the revolutionary advances that have occurred in mass spectrometric technology in the recent past. Today's machines are much smaller, more versatile and more powerful, and we have leveraged our contacts and our own track record in chemical synthesis to obtain a huge discount (>50%) on an instrument that will be the first of its kind in Canada. The requested funds will allow us to replace our critical infrastructure, while also allowing us to break open new areas previously restricted by the limitations of old technology.