MRI Acquisition and Analysis Methods for Image Guided Neurosurgery

磁共振成像（MRI）是一种非常丰富的技术，可以探测无数的脑组织特性。除了革命性的诊断放射学，MRI已成为现代微创图像引导手术的基石，其详细的信息提高了手术精度和安全性，同时降低了总的医疗保健成本。该研究项目的主要目标是开发用于图像引导神经外科的新MRI技术。 更具体地说，该提案集中于开发用于规划深部脑刺激的技术;用于诸如帕金森病的疾病的治疗，包括在大脑的特定结构中手术植入刺激电极。我们的目标是开发MRI方法来精确定位刺激目标，将其神经元连接映射到其他大脑结构，对脑血管进行成像，并将这些数据整合到术前手术规划软件环境中。总的来说，这项工作将推进图像引导神经外科的最新技术，使手术更安全，更有效，同时创造新的工具和技术，广泛应用于诊断医学成像和图像引导手术。

Magnetic resonance imaging (MRI) is an exceptionally rich technology that enables probing of a myriad of brain tissue properties. In addition to revolutionizing diagnostic radiology, MRI has become a cornerstone in modern minimally invasive image-guided surgery where its detailed information improves surgical precision and safety while reducing total health care costs. The broad goal of this research program is the development of new MRI technologies for use in image-guided neurosurgery. More specifically, this proposal is focused on the development of technologies for planning deep brain stimulation; a treatment for disorders, such as Parkinson's disease, consisting of the surgical implantation of stimulation electrodes in specific structures of the brain. Our objectives are to develop MRI methods to precisely localize the stimulation targets, to map their neuronal connections to other brain structures, to image the cerebral blood vessels, and to integrate these data within a preoperative surgical planning software environment. Collectively, this work will advance the state-of-the-art in image-guided neurosurgery, making the procedure safer and more effective, while creating new tools and techniques with broad applications in diagnostic medical imaging and image-guided surgery.