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Revealing secrets of cellular phosphorylation systems using mass spectrometry

Revealing secrets of cellular phosphorylation systems using mass spectrometry
使用质谱揭示细胞磷酸化系统的秘密
批准号:
298468-2009
负责人:
Vacratsis, Panayiotis
金额:
$2.7万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2014
资助国家:
加拿大
项目状态:
已结题
起止时间:
2014-01-01 至 2015-12-31

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中文摘要
翻译
可逆磷酸化是一种蛋白质修饰,它被用作开启和关闭酶活性的“光开关”。这一过程的正确执行对于包括细胞生长、发育、新陈代谢和生存在内的一系列生物事件至关重要。为了实现细胞组织和避免疾病状态的促进,穿上和脱去这个化学基团的激酶和磷酸酶必须受到严格的控制。因此,我们研究计划的一个主要主题是了解更多鲜为人知的激酶和磷酸酶,它们被预测在关键的细胞过程中发挥作用,如细胞生长和生存。
英文摘要
Reversible phosphorylation is a protein modification utilized as a "light switch" to turn the activity of enzymes on and off. Proper execution of this process is vital for a vast array of biological events including cellular growth, development, metabolism, and survival. The kinase and phosphatase enzymes that put on and take off this chemical group must be under tight control in order to achieve cellular organization and avoid promotion of disease states. Therefore, a major theme of our research program is to learn more about poorly understood kinases and phosphatases predicted to function in critical cellular processes such as cellular growth and survival.
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Revealing Secrets of Cellular Phosphorylation Systems Using Biological Mass Spectrometry
  • 批准号:
    RGPIN-2020-05099
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.33万
  • 财政年份:
    2022
  • 负责人:
    Vacratsis, Panayiotis
  • 依托单位:
Revealing Secrets of Cellular Phosphorylation Systems Using Biological Mass Spectrometry
  • 批准号:
    RGPIN-2020-05099
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.33万
  • 财政年份:
    2021
  • 负责人:
    Vacratsis, Panayiotis
  • 依托单位:
Revealing Secrets of Cellular Phosphorylation Systems Using Biological Mass Spectrometry
  • 批准号:
    RGPIN-2020-05099
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.33万
  • 财政年份:
    2020
  • 负责人:
    Vacratsis, Panayiotis
  • 依托单位:
Revealing Secrets of Cellular Phosphorylation Systems Using Mass Spectrometry
  • 批准号:
    RGPIN-2015-06000
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.77万
  • 财政年份:
    2019
  • 负责人:
    Vacratsis, Panayiotis
  • 依托单位:
海外基金