Engineering intelligent PLGA nanoparticles for site-specific delivery

制药研究的一个基本问题是开发药物递送方法，可以选择性地针对某些细胞，同时限制周围健康细胞接触药物，以避免附带损害。纳米颗粒（NPs）的进步正在迅速发展，并为药物输送提供了令人兴奋的前景。聚合物NPs，我主要关注的传递系统，是药物传递的通用平台，因为它们大小合适，可以被细胞吸收，具有可物理或化学修饰的大表面积，与其他药物传递系统相比，具有良好的安全性记录。

One fundamental quest in pharmaceutical research is developing methods of drug delivery that can selectively target certain cells, while limiting exposure of surrounding healthy cells to the drug to avoid collateral damage. Advancements in nanoparticles (NPs) are rapidly progressing and offer exciting promise for drug delivery. Polymeric NPs, the delivery system I primarily focus upon, are versatile platforms for drug delivery as they are of appropriate size to be taken up by cells, have a large surface area that can be physically or chemically modified, and an excellent record of safety compared to other drug delivery systems.