Conjugation and intracellular delivery of biomolecular cargo
Conjugation and intracellular delivery of biomolecular cargo
批准号:
470366-2014
负责人:
Keillor, Jeffrey
金额:
$1.82万
依托单位:
依托单位国家:
加拿大
项目类别:
Engage Grants Program
财政年份:
2014
资助国家:
加拿大
项目状态:
已结题
起止时间:
2014-01-01 至 2015-12-31
中文摘要
iProgen开发了一系列细胞可渗透肽,能够将与其融合的大货物生物分子递送到人细胞中。iProgen有兴趣应用这项技术来递送各种生物相关的货物分子。iProgen Biotech和Keillor博士将合作设计、合成和评估一种模块化连接技术,用于将不同的生物相关货物分子连接到细胞可渗透肽上。这种技术的开发将扩大iProgen技术可以提供的货物范围,并加快筛选合适的药物货物和增强的递送剂的过程。这种模块化缀合技术的成功验证也将导致有前途的新治疗技术的发展,这将有利于人类健康。
英文摘要
iProgen has developed a series of cell permeable peptides capable of delivering large cargo biomolecules, to which they are fused, into human cells. iProgen is interested in applying this technology to deliver a variety of biologically relevant cargo molecules. iProgen Biotech and Dr. Keillor will collaborate on the design, synthesis and evaluation of a modular linking technology for attaching different biologically relevant cargo molecules to the cell permeable peptides. The development of such technology will expand the range of cargo that iProgen's technology can deliver, as well as accelerate the process of screening for both suitable drug cargoes and enhanced delivery agents. The successful validation of this modular conjugation technology will also result in the development of promising new therapeutics technology that will benefit human health.
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会议论文
Chemical Biology of Transglutaminases
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批准号:RGPIN-2019-05893
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.76万
-
财政年份:2022
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负责人:Keillor, Jeffrey
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依托单位:
Chemical Biology of Transglutaminases
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批准号:RGPIN-2019-05893
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.76万
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财政年份:2021
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负责人:Keillor, Jeffrey
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依托单位:
Chemical Biology of Transglutaminases
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批准号:RGPIN-2019-05893
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.76万
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财政年份:2020
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负责人:Keillor, Jeffrey
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依托单位:
Chemical Biology of Transglutaminases
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批准号:RGPIN-2019-05893
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.76万
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财政年份:2019
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负责人:Keillor, Jeffrey
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依托单位:
New Methods for Site-Specific Protein Labelling
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批准号:RGPIN-2014-04702
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.95万
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财政年份:2018
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负责人:Keillor, Jeffrey
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依托单位:
New Methods for Site-Specific Protein Labelling
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批准号:RGPIN-2014-04702
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.95万
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财政年份:2017
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负责人:Keillor, Jeffrey
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依托单位:
New Methods for Site-Specific Protein Labelling
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批准号:RGPIN-2014-04702
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.95万
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财政年份:2016
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负责人:Keillor, Jeffrey
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依托单位:
New Methods for Site-Specific Protein Labelling
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批准号:RGPIN-2014-04702
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.95万
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财政年份:2015
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负责人:Keillor, Jeffrey
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依托单位:
New Methods for Site-Specific Protein Labelling
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批准号:RGPIN-2014-04702
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.95万
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财政年份:2014
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负责人:Keillor, Jeffrey
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依托单位:
Fluorogenic labelling of proteins in living cells
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批准号:452040-2013
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项目类别:Idea to Innovation
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资助金额:$8.77万
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财政年份:2013
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负责人:Keillor, Jeffrey
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依托单位:
Bioorganic chemistry of transpeptidases
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批准号:184034-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.46万
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财政年份:2013
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负责人:Keillor, Jeffrey
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依托单位:
Bioorganic chemistry of transpeptidases
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批准号:184034-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.46万
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财政年份:2012
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负责人:Keillor, Jeffrey
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依托单位:
Bioorganic chemistry of transpeptidases
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批准号:184034-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.46万
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财政年份:2011
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负责人:Keillor, Jeffrey
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依托单位:
Bioorganic chemistry of transpeptidases
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批准号:184034-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.46万
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财政年份:2010
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负责人:Keillor, Jeffrey
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依托单位:
Bioorganic chemistry of transpeptidases
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批准号:184034-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.46万
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财政年份:2009
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负责人:Keillor, Jeffrey
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依托单位:
Investigation of transpeptidases
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批准号:184034-2004
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.1万
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财政年份:2008
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负责人:Keillor, Jeffrey
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依托单位:
Investigation of transpeptidases
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批准号:184034-2004
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.1万
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财政年份:2007
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负责人:Keillor, Jeffrey
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依托单位:
Investigation of transpeptidases
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批准号:184034-2004
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.1万
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财政年份:2006
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负责人:Keillor, Jeffrey
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依托单位:
Investigation of transpeptidases
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批准号:184034-2004
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.1万
-
财政年份:2005
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负责人:Keillor, Jeffrey
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依托单位:
Investigation of transpeptidases
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批准号:184034-2004
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.1万
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财政年份:2004
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负责人:Keillor, Jeffrey
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依托单位:
国内基金
海外基金
TAG1/APP信号通路调控的miRNA及其在神经前体细胞增殖和分化中的作用机制
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批准号:31171313
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项目类别:面上项目
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资助金额:60.0万元
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批准年份:2011
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负责人:马全红
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依托单位:
吸入性全身麻醉药致发育神经元毒性的受体-细胞内钙稳态阶段特异性机制及干预研究
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批准号:30772086
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项目类别:面上项目
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资助金额:30.0万元
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批准年份:2007
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负责人:罗爱林
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依托单位: