Optical Uncaging of Neurotransmitters
Optical Uncaging of Neurotransmitters
批准号:
472348-2015
负责人:
Woodin, Melanie
金额:
$8.65万
依托单位:
依托单位国家:
加拿大
项目类别:
Research Tools and Instruments - Category 1 (<$150,000)
财政年份:
2014
资助国家:
加拿大
项目状态:
已结题
起止时间:
2014-01-01 至 2015-12-31
中文摘要
突触抑制是大脑正常运作的关键。我的实验室专注于理解特定神经元群在产生突触抑制中的作用。我们通过结合强大的技术来进行这些实验;在对神经元进行电记录的同时,我们使用最新开发的光遗传学和化学遗传学技术刺激或沉默活动。光遗传学允许研究人员在“开关开关”时激活或沉默基因目标神经元;这项技术的革命性力量使它被命名为年度自然方法(2010)。
英文摘要
Synaptic inhibition is critical for the brain to function properly. My lab is focused on understanding the role of particular groups of neurons in generating this synaptic inhibition. We are preforming these experiments by combining powerful techniques; while making electrical recordings from neurons we stimulate or silence activity using the recently developed optogenetic and chemogenetic technologies. Optogenetics allows researchers to activate or silence genetically targeted neurons at the 'flick-of-a-switch'; the revolutionary power of this technique is what led to it being named the Nature Method of the Year (2010).
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会议论文
Inhibitory Synaptic Plasticity
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批准号:RGPIN-2020-04793
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.23万
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财政年份:2022
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负责人:Woodin, Melanie
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依托单位:
Inhibitory Synaptic Plasticity
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批准号:RGPIN-2020-04793
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.23万
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财政年份:2021
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负责人:Woodin, Melanie
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依托单位:
Inhibitory Synaptic Plasticity
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批准号:RGPIN-2015-03752
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.77万
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财政年份:2019
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负责人:Woodin, Melanie
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依托单位:
Inhibitory Synaptic Plasticity
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批准号:RGPIN-2015-03752
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.77万
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财政年份:2018
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负责人:Woodin, Melanie
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依托单位:
Inhibitory Synaptic Plasticity
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批准号:RGPIN-2015-03752
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.77万
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财政年份:2017
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负责人:Woodin, Melanie
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依托单位:
Inhibitory Synaptic Plasticity
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批准号:RGPIN-2015-03752
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.77万
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财政年份:2016
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负责人:Woodin, Melanie
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依托单位:
Inhibitory Synaptic Plasticity
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批准号:RGPIN-2015-03752
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.77万
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财政年份:2015
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负责人:Woodin, Melanie
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依托单位:
Disinhibition-mediated long-term potentiation
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批准号:293196-2010
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.91万
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财政年份:2014
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负责人:Woodin, Melanie
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依托单位:
Disinhibition-mediated long-term potentiation
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批准号:293196-2010
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.91万
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财政年份:2013
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负责人:Woodin, Melanie
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依托单位:
Disinhibition-mediated long-term potentiation
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批准号:293196-2010
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.91万
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财政年份:2012
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负责人:Woodin, Melanie
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依托单位:
Disinhibition-mediated long-term potentiation
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批准号:396034-2010
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项目类别:Discovery Grants Program - Accelerator Supplements
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资助金额:$2.91万
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财政年份:2012
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负责人:Woodin, Melanie
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依托单位:
Multi-wavelength Patterned Illuminator for Optogenetic Stimulation of Neurons
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批准号:439829-2013
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项目类别:Research Tools and Instruments - Category 1 (<$150,000)
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资助金额:$0.56万
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财政年份:2012
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负责人:Woodin, Melanie
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依托单位:
Disinhibition-mediated long-term potentiation
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批准号:293196-2010
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.91万
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财政年份:2011
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负责人:Woodin, Melanie
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依托单位:
Disinhibition-mediated long-term potentiation
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批准号:396034-2010
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项目类别:Discovery Grants Program - Accelerator Supplements
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资助金额:$2.91万
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财政年份:2011
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负责人:Woodin, Melanie
-
依托单位:
Disinhibition-mediated long-term potentiation
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批准号:396034-2010
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项目类别:Discovery Grants Program - Accelerator Supplements
-
资助金额:$2.91万
-
财政年份:2010
-
负责人:Woodin, Melanie
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依托单位:
Disinhibition-mediated long-term potentiation
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批准号:293196-2010
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.91万
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财政年份:2010
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负责人:Woodin, Melanie
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依托单位:
Nucleofection of cultured hippocampal neurons
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批准号:390105-2010
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项目类别:Research Tools and Instruments - Category 1 (<$150,000)
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资助金额:$1.79万
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财政年份:2009
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负责人:Woodin, Melanie
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依托单位:
Spike-timing dependent plasticity of GABAergic synapses in the hippocampus
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批准号:293196-2007
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.09万
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财政年份:2009
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负责人:Woodin, Melanie
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依托单位:
Activity-Induced Plasticity of Inhibitory Synapses
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批准号:299453-2004
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项目类别:University Faculty Award
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资助金额:$2.91万
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财政年份:2008
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负责人:Woodin, Melanie
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依托单位:
Spike-timing dependent plasticity of GABAergic synapses in the hippocampus
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批准号:293196-2007
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.09万
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财政年份:2008
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负责人:Woodin, Melanie
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依托单位:
海外基金