Continuous flow IR for reaction discovery and optimization

几代人以来，散装化学工业一直在使用连续工艺，以安全和可扩展的方式生产大量材料。学术和制药实验室现在开始迎头赶上，迅速采用新的“流动化学”技术，以实现更快、更可持续的反应。在FLOW中开发的过程可以很容易地在小规模和大规模进行，缩小了基础发现和工业应用之间的差距。我们的研究重点是在流程中发现和优化新的化学物质，以确保加拿大的化学工业在未来几年可持续和盈利。这种反应设计方法受到现有分析技术的限制。提出了对实时监控物质组成的连续流动IR的请求。快速反馈将使我们的团队能够设计高效的反应堆，集成废品回收，提供更经济、可持续和可扩展的化学工艺。还将探索反应开发的自动化，集成优化化学反应器的所有组件，以实现计算机控制的反应执行、分析和解释，影响世界各地的化学家和工程师努力实现可持续的未来。所要求的设备将是魁北克/安大略省地区的第一个此类设备，对于启动国家和国际合作以及培训总部主管对化学工业重要的技能，如化学合成、动力学分析和反应堆设计，将是一个非常有价值的工具。

The bulk chemical industry has been using continuous processes for generations to produce large quantities of material in a safe and scalable manner. Academic and pharmaceutical laboratories are now starting to catch up, rapidly adopting new 'flow chemistry' technologies to achieve faster, more sustainable reactions. Processes developed in flow can be readily carried out on small and large scale, narrowing the gap between fundamental discoveries and industrial application. Our research focuses on the discovery and optimization of new chemistry in flow for ensuring that the chemical industry in Canada is sustainable and profitable over the coming years. This approach to reaction design is bottle-necked by available techniques for analysis. A request is made for a continuous flow IR that monitors composition of matter in real-time. Rapid feedback will allow our groups to design efficient reactors with integrated recycling of waste products, providing more economical, sustainable and scalable chemical processes. Automation of reaction development will also be explored by integrating all components of the optimized chemical reactor for computer-controlled reaction execution, analysis, and interpretation, impacting chemists and engineers around the world working towards a sustainable future. The requested equipment would be the first of its kind in the Quebec/Ontario region, and would be a highly valuable tool for initiating national and international collaborations as well as for training HQP in skills important to the chemical industry such as chemical synthesis, kinetic analysis, and reactor design.