(un)Conscious use of Sensation For Action

拿起一杯咖啡的简单动作需要大脑执行一系列复杂的感觉到运动的转换。具体来说，大脑必须使用视觉信息来定位杯子，以及视觉和本体感受信息（例如来自关节和肢体角度的信息）来定位手。然而，需要处理的信息量是巨大的，必须在处理之前缩减。此外，很明显，有时候人们并不能有意地控制自己的行为（考虑一下棒球中你知道你不应该的投球）。因此，本研究计划的短期目标是：（1）检查限制有意识地获取运动规划和控制所需的体感信息的机制;（2）了解意志判断在选择和优化视觉信息中的作用。追求这些目标将继续推进我的研究计划，实现其长期目标：更好地了解支持日常生活活动的准备和执行的过程和皮层基础。简而言之，神经系统如何决定使用哪些信息，忽略哪些信息，以及在做出这些决定之前，神经系统如何利用相关的输入？这将通过使用2个核心范例-触觉门控和感觉预提示进行检查。将使用运动学分析和神经生理学（TMS和EEG）组合来表征行为并探测潜在的神经过程。为了实现这些目标，提出了一些研究来测试以下问题：1A：触觉门控的空间和时间特性的变化作为一个函数的时间和多感官信息的可用性？ 1B：触觉门控的大小是否会随任务目标的功能相关性而变化？ 1C：触觉门控主要是皮层的，是由额叶和顶叶到达网络之间的前馈相互作用产生的吗？ 2A：目标编码的程度和皮质基础是否会根据即将发生的感觉事件的可用性和可预测性而变化？ 2B：关于最佳效应器选择的线索可以整合到运动计划中吗？这些实验的结果将大大增加我们对人类神经系统如何处理这种信息障碍的皮层和行为基础的理解。除了这一核心的基本理解，这些发现将对我们理解临床综合征（例如，意图震颤，自闭症）以及高级技能表现（例如，手术、飞行训练）。

The simple act of picking up a cup of coffee requires the brain to perform a complex series of sensory to motor transformations. Specifically, the brain must use visual information to locate the cup, and visual and proprioceptive information (e.g. information derived from joint and limb angles) to locate the hand. However, the volume of information necessary to be processed is immense and must be curtailed prior to processing. Further, it is clear that sometimes people are not in intentional control of their actions (consider swinging at a pitch in baseball that you know you should not). Thus, the short-term objectives of this research program are to (1) examine the mechanisms that limit conscious access to somatosensory information necessary for movement planning and control and (2) understand the role volitional judgement plays in the selection and optimization of visual information for action. Pursuit of these objectives will continue to advance my research program towards its long-term objective: to better understand the processes and cortical underpinnings supporting the preparation and execution of activities of daily living. In short, how does the nervous system decide which information to use, which information to ignore, and, pending these decisions, how the nervous system utilizes the relevant inputs? This will be examined using through 2 core paradigms -- tactile gating and sensory pre-cueing. A combination kinematic analyses and neurophysiological (TMS and EEG) will be used to characterize the behaviours and probe the underlying neural processes. In order to accomplish these objectives, a number of studies are proposed to test the following questions: 1A: Do the spatial and temporal characteristics of tactile gating change as a function of time and multi-sensory information availability? 1B:Will The magnitude of tactile gating vary with functional relevance to the task goal? 1C: Is tactile gating primarily cortical and generated by feed-forward interactions between frontal and parietal reaching networks? 2A: Do the degree and cortical basis of target encoding vary based on the availability and predictability upcoming sensory events? 2B: Can cues regarding optimal effector selection be integrated into the motor plan? These results of the proposed experiments will significantly increase our understanding of the cortical and behavioural basis for how human nervous system addresses this information barrage. Beyond this core basic understanding, these finding will have critical implications to our understanding of clinical syndromes (e.g., intention tremour, Autism) as well advanced skill performance (e.g., surgery, flight-training).