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Investigation of the sequential development of integrase strand transfer inhibitor resistance mutations in HIV.

Investigation of the sequential development of integrase strand transfer inhibitor resistance mutations in HIV.
研究 HIV 整合酶链转移抑制剂耐药突变的顺序发展。
批准号:
324345
负责人:
Anstett Kaitlin
金额:
$0.11万
依托单位:
依托单位国家:
加拿大
项目类别:
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-01-01 至 2016-01-01

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中文摘要
翻译
尽管抗逆转录病毒疗法(ARV)已经挽救了许多HIV阳性患者的生命,但耐药性威胁着其长期疗效。In是一种HIV蛋白质,对于将病毒DNA整合到宿主的基因组中是必不可少的,宿主基因组是一种鲫鱼
英文摘要
Although antiretroviral therapy (ARV) has been lifesaving for many HIV-positive individuals, drug resistance threatens its long-term efficacy. IN is a HIV protein that is essential for the integration of viral DNA into the host's genome, which is a crucia
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会议论文
The Modulation of R263K-Mediated HIV-1 Resistance to Integrase Strand Transfer Inhibitors by Acetylation.
  • 批准号:
    347939
  • 项目类别:
    Studentship Programs
  • 资助金额:
    $7.65万
  • 财政年份:
    2015
  • 负责人:
    Anstett Kaitlin
  • 依托单位:
Characterization of Dolutegravir Resistance Mutation R263K by Combination with Primary INSTI Resistance Mutations
  • 批准号:
    311375
  • 项目类别:
  • 资助金额:
    $0.11万
  • 财政年份:
    2014
  • 负责人:
    Anstett Kaitlin
  • 依托单位:
Further Characterization of the Dolutegravir Resistance Mutation R263K: Combinations with Primary INSTI Resistance Mutations and Possible Compensatory Mechanisms
  • 批准号:
    311953
  • 项目类别:
    Studentship Programs
  • 资助金额:
    $1.27万
  • 财政年份:
    2013
  • 负责人:
    Anstett Kaitlin
  • 依托单位:
海外基金