Ubiquitous Biomedical Sensory Microsystems

本申请中提出的研究计划的长期目标是开发模拟和数字VLSI电路，架构和算法，以实现一次性，可穿戴和植入式微系统的新实现，以解决生物学和医学中关键的未满足的无处不在的传感需求。我们的短期目标是在高影响力应用中设计，原型化，实验表征和验证以下两个这样的感觉微系统： 用于治疗神经系统疾病的完全植入式无线脑接口 一次性无线电化学DNA分析微系统 拟议的生物医学传感系统的普遍存在的原因是双重的。首先，它们是微型的，便宜的，多功能的和自主操作的，这使得它们能够在临床环境内外广泛使用。其次，这些传感器的集合可以用于监测许多生命体征，并执行各种类型的自动医疗诊断，以及在某些情况下，自动治疗。为了方便使用，并消除昂贵的布线和包装，每个传感器都有一个完全无线的接口。 该研究计划是跨学科的，具有合作性质。该申请的重点是集成电路的新功能和性能优化，这些集成电路作为这些无处不在的生物医学传感微系统的传感和计算核心。

The long-term objective of the research program proposed in this application for renewed funding is to develop analog and digital VLSI circuits, architectures and algorithms to enable novel implementations of disposable, wearable and implantable microsystems in order to address key unmet ubiquitous sensing needs in biology and medicine. Our short-term goal is to design, prototype, experimentally characterize and validate in high-impact applications the following two such sensory microsystems: Fully-implantable wireless brain interface for treatment of neurological disorders Disposable wireless electrochemical DNA analysis microsystem The reason for the ubiquity of the proposed biomedical sensory systems is two-fold. First, they are miniature, inexpensive, versatile and autonomously operating, which enables their widespread utilization, both within and outside of clinical settings. Second, a collection of such sensors can be used to monitor a number of vital signs, and perform various types of automated medical diagnostics and, in some cases, automated treatment. In order to facilitate their use, and to eliminate expensive wiring and packaging, each sensor has a fully wireless interface. This research program is cross-disciplinary and has a collaborative nature. The focus of this application for funding is on the novel functionality and performance optimization of integrated circuits which serve as the sensory and computational core of these ubiquitous biomedical sensory microsystems.