Neural noise in human cognitive ageing and reserve

与年龄相关的神经噪音增加会降低大脑中的信息传递，并导致认知功能减弱。然而，由于认知储备，一些人能够在晚年保持健康的功能。本项目旨在研究神经噪声对大脑连通性、认知表现和储备的影响，推进神经生理学在健康认知老化和神经噪声延展性方面的突破性工作。这将通过电生理学、神经成像和非侵入性脑刺激的新组合来实现。从开发用于测量认知储备的神经标记物到建立对与年龄相关的认知衰退的复原力的新策略，这些都是有益的。

Age-related increases in neural noise degrade information transfer in the brain and lead to diminished cognitive function. Yet with cognitive reserve, some people are able to maintain healthy functioning well into their later years. This project aims to investigate the effects of neural noise on brain connectivity, cognitive performance and reserve, advancing breakthrough work on the neural physiology of healthy cognitive ageing and malleability of neural noise. This will be delivered by novel combinations of electrophysiology, neuroimaging and non-invasive brain stimulation. Benefits extend from developing neural markers for measuring cognitive reserve to new strategies for building resilience to age-related cognitive decline.