Hyperbranched polyglycerol-based colloid preservation solutions: Toward clinical applications

当一个器官，如肾脏、心脏和肝脏不再工作时，医生会考虑器官移植来治疗 挽救病人的生命。器官移植是一种外科手术，它包括从一个身体上切除器官，并 但是，在这个过程中，由于没有血液供应，器官会受到损害。一种需要限制的技术 这种损伤是将器官保存在低温保存液中。目前使用几种不同的冷藏保鲜剂 在器官移植中取得了不同程度的成功，但没有一种看起来是完美的，因为损伤仍然 如此之大，以至于许多移植后都不起作用。也是因为对捐赠者器官损害的预防不力 这些解决方案，不太理想的器官，如那些年龄超过55岁的捐赠者，不能接受 移植。这一问题不仅增加了这些移植患者的医疗费用，而且影响了患者的生存 移植后的器官因移植受损，还会减少供体器官的使用恶化 捐献器官的短缺。我们在这个项目中的目标是开发一种新的冷藏溶液，该溶液基于一种新型的 一种化学物质(称为聚甘油聚合物)，可为器官在冷藏或冷冻保存过程中免受损害提供最佳保护 移植。我们完成了这个项目的初步研究，但需要CIHR/NSERC的资金支持才能理解 它是如何工作的，并进一步证明了我们的新溶液对所有不同器官的冷保存的有益效果 在我们被允许在医院测试它之前，临床前的模型。

When an organ, such as the kidney, heart and liver, does not work anymore, a doctor will consider organ transplantation to save the patients life. Organ transplantation is a surgical procedure that consists of removing an organ from one body and implanting it to another; however, damage to the organ occurs in this process due to no blood supply. One technique to limit this damage is to preserve the organ in a cold preservation solution. Several different cold preservations are currently used in the organ transplantation with varying degrees of success, but none of them appears perfect because the damage is still so big, many of transplants do not work after transplantation. Also because of poor prevention of donor organ damage by these solutions, less ideal organs, such as from those donors age greater than 55 years, could not be acceptable for transplantation. This problem not only increases the cost of health care of these transplant patients and affects the survival of the implanted organ afterwards because of transplant damage, but also decreases the use of donor organs worsening the shortage of donor organs. Our objective in this project is to develop a new cold preservation solution based on a novel chemical (called polyglycerol polymer) that will give the best protection of the organ from damage during cold preservation or transplantation. We finished preliminary study for this project, but need financial support from CIHR/NSERC to understand how it works, and further prove the beneficial effects of our novel solution on cold preservation of the organs in all different preclinical models before we are allowed to test it in the hospital.