3D printed bioresorbable sleeve device for esophageal atresia repair

用于食管闭锁修复的3D打印生物可吸收套筒装置

基本信息

  • 批准号:
    10710202
  • 负责人:
  • 金额:
    $ 24.22万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-26 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract Congenital esophageal atresia (EA) is a potentially lethal and relatively common malformation that results in a complete discontinuity of the esophagus. Left untreated, neonates with this condition are unable to eat, choke on their own saliva, and eventually die from end-stage respiratory failure secondary to chronic aspiration pneumonia. Although neonatal primary surgical repair, which restores continuity between the two ends of the esophagus, is a life-saving operation, the procedure is technically difficult in many patients and remains fraught with a high rate of postoperative complications, including leaks, recurrent strictures, fistulae, gastroesophageal reflux, and chronic dysphagia. Moreover, in a subset of newborns (10%) where the gap between the two esophageal ends measures >3 cm (long-gap EA), connecting the ends surgically is impossible, resulting in months of hospitalization because of the need to perform highly morbid esophageal replacement procedures and/or other complex operations. There remains a critical need for novel treatment strategies that can facilitate better outcomes in these newborns. Our long-term goal is to develop regenerative medicine-based treatment strategies for newborns with EA using 3D printed (3DP) elastomeric materials that can improve anastomotic wound healing and decrease complications. The central hypothesis of this project is that the implantation of an external scaffold sleeve made from the elastomer, poly-glycerol-dodecanedioate (PGD), and functionalized with bioactive peptide sequences can improve esophageal anastomotic healing at the EA repair site by reducing tension at the anastomosis and enhancing cell attachment. This proposal tests this hypothesis with two specific aims. In Aim 1, the investigators will determine how scaffold design affects the degradation and biomechanical properties of bioresorbable esophageal sleeves. In Aim 2, the investigators will evaluate bioresorbable esophageal sleeves optimized for anastomotic healing in a neonatal large animal model of EA repair. Completion of these Aims will have advanced the concept of nonlinear elastic resorbable elastomers as a novel approach to modulate the local esophageal tissue microenvironment through cell recruitment and modulation of longitudinal and radial forces. In addition, we anticipate that these experiments will facilitate clinical translation of 3DP device technologies for use by pediatric surgeons in the operating room, leveraging our patient clinical experience with tracheal devices. Finally, our approach will also have set the stage for the development of elastomeric devices as a substrate for the generation of full-thickness segmental tissue for long-gap EA.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Scott J Hollister其他文献

emIn vitro/em fatigue behavior and emin vivo/em osseointegration of the auxetic porous bone screw
负泊松比多孔骨螺钉的体外疲劳行为和体内骨整合
  • DOI:
    10.1016/j.actbio.2023.08.040
  • 发表时间:
    2023-10-15
  • 期刊:
  • 影响因子:
    9.600
  • 作者:
    Lizhen Wang;Huiwen Huang;Hao Yuan;Yan Yao;Jeong Hun Park;Jinglong Liu;Xuezheng Geng;Kuo Zhang;Scott J Hollister;Yubo Fan
  • 通讯作者:
    Yubo Fan

Scott J Hollister的其他文献

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{{ truncateString('Scott J Hollister', 18)}}的其他基金

3D printed bioresorbable sleeve device for esophageal atresia repair
用于食管闭锁修复的3D打印生物可吸收套筒装置
  • 批准号:
    10574363
  • 财政年份:
    2022
  • 资助金额:
    $ 24.22万
  • 项目类别:
Degradation and Fatigue Behavior of 3D Printed Bioresorbable Tracheal Splints
3D 打印生物可吸收气管夹板的降解和疲劳行为
  • 批准号:
    9751354
  • 财政年份:
    2016
  • 资助金额:
    $ 24.22万
  • 项目类别:
PGD: A Shape Memory Degradable Polymer for Transcather Atrial Sept
PGD​​:用于经导管心房间隔的形状记忆可降解聚合物
  • 批准号:
    9496292
  • 财政年份:
    2016
  • 资助金额:
    $ 24.22万
  • 项目类别:
Integrated Structural BMP2 Carrier Systems for Cervical Spine Fusion
用于颈椎融合的集成结构 BMP2 载体系统
  • 批准号:
    8544773
  • 财政年份:
    2011
  • 资助金额:
    $ 24.22万
  • 项目类别:
Integrated Structural BMP2 Carrier Systems for Cervical Spine Fusion (resubmissi
用于颈椎融合的集成结构 BMP2 载体系统(重新提交
  • 批准号:
    8239266
  • 财政年份:
    2011
  • 资助金额:
    $ 24.22万
  • 项目类别:
Integrated Structural BMP2 Carrier Systems for Cervical Spine Fusion (resubmissi
用于颈椎融合的集成结构 BMP2 载体系统(重新提交
  • 批准号:
    8334421
  • 财政年份:
    2011
  • 资助金额:
    $ 24.22万
  • 项目类别:
Relative Influence of Scaffold Design/Material Parameters On Bone Regeneration
支架设计/材料参数对骨再生的相对影响
  • 批准号:
    7316356
  • 财政年份:
    2007
  • 资助金额:
    $ 24.22万
  • 项目类别:
Relative Influence of Scaffold Design/Material Parameters On Bone Regeneration
支架设计/材料参数对骨再生的相对影响
  • 批准号:
    8126369
  • 财政年份:
    2007
  • 资助金额:
    $ 24.22万
  • 项目类别:
Relative Influence of Scaffold Design/Material Parameters On Bone Regeneration
支架设计/材料参数对骨再生的相对影响
  • 批准号:
    7656840
  • 财政年份:
    2007
  • 资助金额:
    $ 24.22万
  • 项目类别:
Relative Influence of Scaffold Design/Material Parameters On Bone Regeneration
支架设计/材料参数对骨再生的相对影响
  • 批准号:
    7477348
  • 财政年份:
    2007
  • 资助金额:
    $ 24.22万
  • 项目类别:

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