Development and application of decarboxylative and desulfinative cross-coupling reactions

拟议研究计划的目标：新合成方法的开发和复杂天然产物的构建是合成有机化学的核心。更大的全球意识的出现促使化学家重新审视旧问题，并以一种使转化更有效，更高产和尽可能环境友好的方式解决新问题。我的研究项目主要集中在钯介导的脱羧和反式交叉偶联反应（杂）芳烃形成碳-碳键，这是一个重要的转变，在合成有机化学和药物化学。该反应避免了用金属物质预官能化偶联配偶体的需要。反应的主要副产物二氧化碳或二氧化硫充当反应的驱动力，并且不产生需要纯化步骤来去除的金属基杂质。我的研究将集中在合成噻吩衍生的杂芳族化合物用于材料和医药应用;使用这些方法从简单和/或未充分利用的起始原料在环境友好的条件下合成增值化学品，并清楚地了解转化的操作机制，以提高工业研究用途的实用性。此外，流动化学的应用，这些交叉耦合将被检查。流动化学可能在确保这些转化的实用性方面发挥关键作用，以便使它们对化学工业更有用。一个关键的目标将是使用机械研究作为指导，以回收SO

Objectives of the Proposed Research Program: The development of new synthetic methods and the construction of complex natural products lie at the heart of synthetic organic chemistry. The emergence of a greater global consciousness has pushed chemists to revisit old problems and tackle new ones in a manner that makes transformations more efficient, higher yielding and as environmentally benign as possible. My research program focuses on palladium-mediated decarboxylative and desulfinative cross-coupling reactions of (hetero-)aromatics for the formation of carbon-carbon bonds, which is a vital transformation in both synthetic organic and medicinal chemistry. This reaction circumvents the need for the pre-functionalization of the coupling partner with a metal species. The main by-product of the reaction, carbon dioxide or sulfur dioxide, acts as a driving force for the reaction and does not generate metal-based impurities that require a purification step for their removal. My research will focus on the synthesis of thiophene-derived heteroaromatics for use in materials and medicinal applications; synthesis of value-added chemicals employing these methods from simple and/or underutilized starting materials in environmentally friendly conditions, and gaining a clear understanding of the operative mechanism of the transformation in order to improve the practicality for industrial research use. Additionally, the application of flow-chemistry to these cross-coupling will be examined. Flow-chemistry may play a key role in ensuring the practicality of these transformations in order to render them more useful to the chemical industry. A key aim will be to use the mechanistic studies as a guide to recycle the SO