Molecular Engineering of Deoxyribozymes for Amplified Protein Detection and Cell Imaging

蛋白质是所有生物体的基本组成部分，执行从表达基因组信息到维持体内平衡的大量功能。它们也是一类重要的疾病诊断生物标志物。目前的蛋白质检测技术（例如，ELISA、蛋白质印迹、免疫-PCR）通常需要复杂的仪器、繁琐的操作和具有专门技术的训练有素的人员，因此不适合许多实际用途，例如护理点疾病诊断和高通量分析。我们的研究计划将专注于通过开发新的化学和生物工具来解决蛋白质分析中的当前挑战，其应用范围从基础研究到个性化医疗保健。

Proteins are essential components of all living organisms, performing a vast array of functions ranging from expressing the genomic information to maintaining homeostasis. They are also a class of important biomarkers for disease diagnostics. Current protein detection techniques (e.g., ELISA, Western blot, immuno-PCR) typically require complicated instrumentation, tedious operations, and well-trained personnel with specialized techniques, and thus are not amenable for many practical uses, such as point-of-care disease diagnostics and high throughput analysis. Our research program will focus on addressing current challenges in protein analysis by developing new chemical and biological tools with applications ranging from fundamental research to personalized healthcare.