Prediction of interactions involving intrinsically disordered proteins

固有无序(ID)蛋白在蛋白质相互作用中起着核心作用，因为它们的ID片段经常介导大量的相互作用。我们以前已经证明，由ID蛋白片段介导的相互作用的特征是将它们与其他蛋白质相互作用区分开来。我们假设这些特征可以用来(I)确定球状蛋白上优先与ID蛋白结合的相互作用部位，以及(Ii)确定ID蛋白片段在结合时采用的结构。基于这一假设，我们提出了以下目标：

Intrinsically disordered (ID) proteins play a central role in protein interactomes because their ID segments often mediate large numbers of interactions. We have shown previously that interactions mediated by ID protein segments are characterized by features that distinguish them from other protein interactions. We hypothesize that these features can be used to (i) identify interaction sites on globular proteins that preferentially bind ID proteins and (ii) determine the structures that ID protein segments adopt upon binding. Based on this hypothesis, we propose the following aims: