Refrigeration system to support multi-scale human biomechanics testing and modeling

该提案是对大型制冷系统的要求，该系统将能够对人体生物力学系统和组织中的降解、失效和寿命的基本机制进行多尺度（从全身到个体组织）调查。该系统将提供冷冻和储存多达8个新鲜冷冻、未经防腐处理的全身捐献物的方法，从而能够研究组织和身体行为，这是在活体人类中看到的最佳代表。新鲜冷冻避免了防腐的负面影响，包括关节运动的严重限制，能量吸收减少，以及对冲击，长时间负荷和重复负荷的反应改变。仅在前五年，拟议的制冷系统将实现一个标本供应计划，该计划将支持20名博士，20名硕士和20名本科生在9个NSERC发现补助金资助和2个NSERC加拿大研究主席研究计划中的主要论文研究。

This proposal is a request for a large-scale refrigeration system that will enable multi-scale (from whole body to individual tissues) investigations into fundamental mechanisms of degradation, failure, and longevity in human biomechanical systems and tissues. The system would provide the means to freeze and store up to eight freshly frozen, unembalmed, whole body donations, enabling the study of tissue and body behaviour that is the best possible representation of that seen in living humans. Fresh freezing avoids the negative effects of embalming, including severe limitation of joint motion, decreased energy absorption, and altered response to impact, prolonged loading, and repetitive loads. In the first five years alone, the proposed refrigeration system would enable a specimen provision program that would support primary thesis research for 20 PhD, 20 MSc, and 20 undergraduate students in 9 NSERC Discovery Grant funded and 2 NSERC Canada Research Chair research programs.