Cell biology of a specialized epithelium: regulation of the cellularizing C. elegans germline

极化细胞形状的产生对控制细胞功能很重要，因为它允许在细胞内产生不同的结构域。了解这一过程对细胞生物学至关重要，秀丽隐杆线虫已成为研究极性产生或蛋白质复合物组装的关键模型系统。我们已经开始研究指导多核有丝分裂合胞体生殖细胞（卵母细胞）有序生长和生成的分子调控。两个过程特别重要：侧膜的生长和连接卵母细胞和合胞体的开口（环管）的控制。实现这种组织需要相邻细胞之间的精细协调，收缩性的调节和细胞新生极化结构域的产生。

The generation of a polarized cell shape is important to govern cell function as it allows the production of different domains within that cell. Understanding this process is critical for cell biology, and the nematode C. elegans has become a key model system for the study of generation of polarity or assembly of protein complexes. We have begun to examine the regulation of the molecules that direct the growth and generation of an ordered progression of germ cells (oocytes) from a multinuclear mitotic syncytium. Two processes are particularly important: growth of the lateral membranes and control of the opening (ring canal) that connects the growing oocyte to the syncytium. Achieving this organization requires exquisite coordination between adjacent cells, regulation of contractility and generation of polarized domains of a cell de novo.