Development of a photothermal non-invasive in-vehicle alcohol detection biosensor

中红外（MIR）双波长激光生物传感器（命名为波长调制差分光热辐射测量法，WM-DPTR）的开发和应用是一种快速，无创的全光学血液酒精诊断监测仪，用于在加拿大和潜在的世界范围内打击酒驾，与我们的工业合作伙伴，酒精对抗系统（ACS）， Etobicoke， ON合作。我们之前使用皮肤-葡萄糖-血清幻影扩散到皮肤的研究表明，WM-DPTR在迄今为止的无创技术中对葡萄糖的敏感性最高。WM-DPTR具有类似皮肤-乙醇-血清幻影结构的初步测试表明，在乙醇的情况下，应该期望具有类似的性能。项目目标是开发车载WM-DPTR酒精联锁系统的实验室原型。该CRD提案的主要部分是将生物传感器中的商用双量子级联激光器（QCL）模块替换为单激光模块，以大幅降低商业级（约500个）数量的价格。ACS还与滑铁卢大学合作开发廉价（约500美元）和紧凑型中红外激光器，以支持WM-DPTR技术的商业化。

The development and application of a mid-infrared (MIR) two-wavelength laser-based biosensor (named Wavelength-Modulated Differential Photothermal Radiometry, WM-DPTR) is proposed as a fast, noninvasive all optical blood alcohol diagnostic monitor for use in the fight against drunk driving in Canada and potentially world-wide, in collaboration with our industrial partner, Alcohol Countermeasure Systems (ACS), Etobicoke, ON. Our previous research using a skin-glucose-blood serum phantom diffused into skin demonstrated that WM-DPTR has the highest sensitivity to glucose amongst noninvasive techniques to-date. Preliminary testing of WM-DPTR with a similar skin-ethanol-blood serum phantom configuration showed that similar performance should be expected in the case of ethanol. Project goal is to develop a laboratory prototype of an in-vehicle WM-DPTR alcohol interlock system. A major part of this CRD Proposal is to replace the commercial two-quantum cascade laser (QCL)-module in the biosensor with one-laser-module for substantial price decrease at commercial-level (~ 500) quantities. ACS is also collaborating with the University of Waterloo for the development of inexpensive (~$500) and compact mid-IR lasers for supporting the commercialization of WM-DPTR technology.