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Determining the role of histone modifications in mediating transcriptional consistency in beta-cells and in diabetes pathogenesis

Determining the role of histone modifications in mediating transcriptional consistency in beta-cells and in diabetes pathogenesis
确定组蛋白修饰在介导 β 细胞转录一致性和糖尿病发病机制中的作用
批准号:
355767
负责人:
Hoffman Brad G
金额:
$54.89万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-10-01 至 2021-10-01

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中文摘要
翻译
在2型糖尿病的发生发展过程中,免疫细胞诱导的炎症和代谢应激导致分泌胰岛素的β细胞失去正常功能。这在一定程度上是因为贝塔细胞的水平降低或关键基因有助于
英文摘要
During the development of type 2 diabetes immune cell induced inflammation and metabolic stress induce insulin secreting beta-cells to lose their normal functionality. In part this is because the beta-cells have reduced levels or critical genes that help
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会议论文
Determining Myt3's role in beta-cell maturation, function and inflammatory response.
Functional analysis of Myt3's role in Beta-cell transcriptional networks and diabetes
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