Replacement of Life Sciences Institute Biomolecular Imager

NSERC资助的研究实验室来自UBC生命科学研究所(LSI)内的3个系和2个系，利用生物分子成像仪开创了广泛的生物化学和分子应用领域。所有这些研究项目都需要灵敏的方法来研究生物分子相互作用，这些相互作用是细胞内生化反应的基础。作为对放射性同位素和荧光/化学发光探测器进行灵敏检测和定量的一台非常先进的主要机器，所要求的GE amersham台风5号成像仪将使申请人能够继续开发解决生物学基本问题的尖端方法。目前，大规模集成电路中现有的所有成像器都不起作用，无法修复，因此迫切需要更换这种成像器。该仪器将允许NSERC资助的研究计划继续开发新的方法，促进进一步的创新，并加强我们在生物科学方面的培训计划。这台第5号台风成像仪将支持申请者继续卓越的研究，这些申请者在过去6年中总共获得了超过1200万美元的研究和培训资金，已经出版了203本出版物和3项专利(1项正在申请中)，并培训了279名HQP。

NSERC-funded research labs from 3 departments and 2 faculties within the UBC Life Sciences Institute (LSI) have pioneered a broad variety of biochemical and molecular applications using biomolecular imagers. All of these research programs require sensitive approaches to study biomolecular interactions that are fundamental to biochemical reactions in the cell. As a highly advanced workhorse machine for the sensitive detection and quantitation of radioisotopes and fluorescent/chemiluminsescent probes, the requested GE Amersham Typhoon 5 imager will allow the applicants to continue developing cutting-edge approaches in addressing fundamental questions in biology. Currently, all existing imagers in the LSI are non-functional and irreparable, thus there is an urgent need to replace this imager. The instrument will allow the NSERC-funded research programs to continue developing new approaches, facilitate further innovation and enhance our training program in the biological sciences. This Typhoon 5 imager will support the continued research excellence of the applicants who over the last 6 years have collectively been awarded more that $12 million in funds for research and training, have produced 203 publications and 3 patents (1 pending), and trained 279 HQP.