Examining nociception with a laser evoked potential stimulator

从激光器发出的辐射热是客观测量伤害性诱发电位的金标准方法。本申请的主要目的是支持购买激光器，用于在不列颠哥伦比亚省（UBC）大学采集诱发电位。这一关键设备对于将UBC的实验室（克雷默博士，申请人和共同申请人拉默博士，Blouin博士和Dumont博士）定位为伤害感受研究的领导者至关重要。激光器建立在现有的核心基础设施（例如，其他刺激器和记录设备），将是UBC的第一个同类产品，并应用于人类和动物研究。激光器的引入扩展了克雷默、拉默、布劳因和杜蒙博士的NSERC发现资助（DG）框架，为每位研究者创建了新的关键研究领域。克雷默博士将专门利用激光刺激器与局部辣椒素的应用相结合，以研究人类继发性痛觉过敏区域的感觉。拉默博士将开发激光诱发电位的应用，作为啮齿动物伤害感受的客观替代措施。最后，Blouin博士将在研究中使用激光评估前庭刺激对伤害性感受的调制。由于接触热的限制（即，不是纯粹有害的和大的刺激区域）。激光还将用于支持正在进行的工作，以改善使用音频信号转换技术采集脑电图（Guy Dumont博士，待定NSERC -与克雷默博士合作的健康研究应用）。除了研究应用的迫切需求外，UBC的激光器将为使用国际公认的金标准仪器培训高素质人员提供令人兴奋的机会，并增加国家合作的前景（例如，拉瓦尔大学）。

Radiant heat emitted from a laser is the gold-standard method for the objective measurement of nociceptive evoked potentials. The central aim of this application is to support the purchase of a laser for the acquisition of evoked potentials at the University of British Columbia (UBC). This key piece of equipment is essential to position laboratories at the UBC (Dr. Kramer, applicant and co-applicants Drs. Ramer, Blouin, and Dumont) as leaders in in the study of nociception. A laser builds on existing core infrastructure (e.g., other stimulators and recording equipment), will be the first of its kind at UBC, and applied in both humans and animal research studies. The incorporation of a laser expands the NSERC Discovery Grant (DG) framework of Drs. Kramer, Ramer, Blouin, and Dumont by creating new and pivotal lines of investigation for each investigator. Dr. Kramer will specifically utilize the laser stimulator in conjunction with the application of topical capsaicin to investigate sensation in the area of secondary hyperalgesia in humans. Dr. Ramer will develop the application of laser evoked potentials as an objective surrogate measure of nociception in rodents. Finally, Dr. Blouin will employ the laser in studies assessing the modulation of nociception with vestibular stimulation. All three lines of investigation are highly dependent on the purchase of a laser stimulator for reasons related to limitations of contact heat (i.e., not purely noxious and large stimulation area). The laser will also be used to support ongoing work to improve the acquisition of electroencephalography using audio signal conversion technology (Dr. Guy Dumont, pending NSERC - Collaborative Health Research application with Dr. Kramer). In addition to the urgent need for research applications, a laser at UBC will provide an exciting opportunity for training of highly qualified personnel using an internationally regarded gold standard instrument and increase prospects for national collaborations (e.g., University of Laval).