Mass spec studio software for the pharmaceutical market - a phase one project

想象一下，在生命科学研究的强大新技术上花费数十万美元，结果却发现你无法充分利用它产生的数据。这是在大量的学术和工业实验室中的情况，这些实验室已经购买了质谱仪用于横跨生物和环境科学的所有领域的研发。质谱学中的新技术刺激了化合物表征新方法的巨大发展，特别是在生物制药行业。生物制药是蛋白质类药物。它们代表了一类非常有效的药物制剂，该领域正在全球范围内经历高速增长。为了支持新的蛋白质药物的开发，并确保这些复杂药物的安全使用，质谱仪是一种完美的技术选择。制造质谱仪的公司跟不上生物制药公司正在向质谱学发展的许多新方向，预计情况还会进一步恶化。我们为这个问题开发了一个变革性的解决方案，其形式是一个名为质量谱工作室的应用程序构建软件平台。该平台极大地减少了创建新应用程序的开发时间。它目前拥有研究级插件，对于一种被称为高阶结构(HOS)分析的蛋白质表征形式非常有用。在这个项目中，我们将完成质量谱工作室的第二版。它将包含业界领先的用于居屋分析的插件，并进一步简化应用程序开发过程。该项目的目标是创建一套技术，帮助质谱学跟上生物制药行业的需求，并确保蛋白质药物有效和安全。

Imagine spending hundreds of thousands of dollars on powerful new technology for life science research, onlyto discover that you cannot fully use the data that it produces. This is a situation in a large number of academicand industry laboratories that have purchased mass spectrometers for R&D spanning all areas of biological andenvironmental sciences. New technologies in mass spectrometry have spurred tremendous growth in newmethods for compound characterization, especially in the biopharmaceuticals industry. Biopharmaceuticals areprotein drugs. They represent a very effective class of pharmaceutical agents and the area is experiencing ahigh rate of growth worldwide. Mass spectrometry is the perfect choice of technology to support thedevelopment of new protein drugs, and to ensure that these complicated drugs are safe to use. The companiesthat make mass spectrometers are not able to keep up with the many new directions that biopharmaceuticalcompanies are taking mass spectrometry, and the situation is expected to deteriorate further. We developed atransformative solution to this problem, in the form of an application-building software platform called theMass Spec Studio. This platform strongly reduces the development time for creating new applications. It iscurrently houses research-grade plug-ins that are very useful for a form of protein characterization calledhigher-order structure (HOS) analysis. In this project we will complete version 2 of the Mass Spec Studio. Itwill contain industry-leading plug-ins for HOS analysis and streamline the application development processeven further. The goal of the project is to create a package of technologies that will help mass spectrometrykeep pace with the needs of the biopharmaceutical industry, and ensure that protein drugs are effective andsafe.