Functional characterization of proteins associated with promeylocytic leukemia nuclear bodies

真核细胞的绝大多数遗传物质存在于细胞核中，细胞核是一个高度分隔的细胞器。细胞核内有许多亚核区室，它们不一定是遗传物质的避难所，但却作为调节涉及遗传物质的各种核过程的重要中心。这些亚核区室之一被称为早幼粒细胞白血病（PML）核体，其在诱导细胞凋亡和细胞衰老、抑制增殖、维持基因组稳定性和抗病毒应答的调节中发挥重要作用。已经发现超过100种蛋白质永久或短暂地存在于PML体内，然而，它们与这种细胞器的关联的性质、它们彼此之间的相互作用以及它们如何有助于调节各种细胞过程仍然在很大程度上未被表征。的

The vast majority of the genetic material of the eukaryotic cell resides in the nucleus, which is a highly compartmentalized organelle. Within the nucleus are a variety of subnuclear compartments that do not necessarily harbour the genetic material but serve as important centers for regulating a variety of nuclear processes involving the genetic material. One of these subnuclear compartments is known as promyelocytic leukemia (PML) nuclear bodies, which play an important role in the regulation of induction of apoptosis and cellular senescence, inhibition of proliferation, maintenance of genomic stability and the antiviral response. Over 100 proteins have been found to reside, permanently or transiently, in PML bodies, however, the nature of their association with this organelle, their interactions with one another, and how they contribute to the regulation of various cellular processes remains largely uncharacterized. The