Spatial and temporal control of meiosis

卵子激活是一个成熟的卵子被触发完成减数分裂，同时经历关键的发育变化，为随后的胚胎发育做好准备的过程。编码后期促进复合体（APC/C）减数分裂特异性激活因子的cort基因几乎参与了卵子激活的所有方面。少量其他基因也与卵子活化有关，包括CanB2磷酸酶和CycB3-Cdk1。我们研究的一个主要目标是确定这些基因如何相互作用以促进减数分裂的完成。我们也对发现这些细胞周期调节因子如何控制与卵子激活相关的关键发育过程感兴趣。

Egg activation is the process by which a mature egg is triggered to complete meiosis and at the same time to undergo critical developmental changes that prepare the egg for subsequent embryonic development. The cort gene, which encodes a meiosis-specific activator of the Anaphase Promoting Complex (APC/C), is involved in almost all aspects of egg activation. A small number of other genes have also been implicated in egg activation, including the CanB2 phosphatase and CycB3-Cdk1. A major goal of our research is to determine how these genes interact to promote the completion of meiosis. We are also interested in discovering how these cell cycle regulators also control critical developmental processes that are linked to egg activation.