Role of FXR proteins in the cell stress response

MRNA翻译的协调控制是真核细胞动态平衡的基础，特别是在应对生理和病理应激时。这种程序的改变可能导致受损细胞的生长，这是细胞转化和癌症的标志，或者导致细胞过早死亡，如神经退行性变和不孕症。脆性X相关蛋白(FXRP)是一类与RNA结合的蛋白，在mRNA翻译中起关键作用，并具有与细胞应激反应相关的功能。然而，FXRPs调节细胞应对压力所需的mRNA翻译的潜在机制在很大程度上仍不清楚。

The coordinated control of mRNA translation is fundamental for eukaryotic cell homeostasis, particularly in response to physiological and pathological stress. Alterations of this program can lead to the growth of damaged cells, a hallmark of cell transformation and cancer, or to premature cell death, such as observed in neurodegeneration and infertility. Fragile X-related proteins (FXRPs) are RNA-binding proteins that play a key role in mRNA translation and have a function that is associated with cell stress responses. However, the underlying mechanisms by which FXRPs regulate the mRNA translation that is required for a cell to cope with stress remains largely unknown.