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Novel functions of importin-alpha in RNA metabolism and the stress response

Novel functions of importin-alpha in RNA metabolism and the stress response
importin-alpha 在 RNA 代谢和应激反应中的新功能
批准号:
RGPIN-2015-04137
负责人:
Stochaj, Ursula
金额:
$2.77万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-12-31

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中文摘要
翻译
在真核细胞中,importin-a蛋白家族(这里称为importin-a)对细胞生理学的多个方面都有贡献。除了核运输,家庭成员还参与其他重要的生物过程。近年来的研究表明,进口蛋白a在RNA代谢和应激反应中具有新的功能。因此,我们证明了importin-a1与poly(A)-RNA结合。我们还发现,进口蛋白a家族的多个成员与细胞质应激颗粒(SGs)有关。进口蛋白a是如何参与这些关键的细胞活动的还不清楚。我们的研究计划将解决这些核心的生物学问题。
英文摘要
In eukaryotic cells, the importin-a protein family (here referred to as importin-a) contributes to multiple aspects of cell physiology. Aside from nuclear transport, family members are implicated in additional vital biological processes. Recent studies suggest that importin-a has new functions in RNA metabolism and the stress response. Thus, we demonstrated that importin-a1 binds poly(A)-RNA. We also showed that multiple members of the importin-a family associate with cytoplasmic stress granules (SGs). How importin-a proteins contribute to these crucial cellular activities is not well understood. Our research program will address these central biological questions.
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Novel functions of nuclear transport factors in cellular homeostasis
  • 批准号:
    RGPIN-2020-05104
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.33万
  • 财政年份:
    2022
  • 负责人:
    Stochaj, Ursula
  • 依托单位:
Novel functions of nuclear transport factors in cellular homeostasis
  • 批准号:
    RGPIN-2020-05104
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.33万
  • 财政年份:
    2021
  • 负责人:
    Stochaj, Ursula
  • 依托单位:
Novel functions of nuclear transport factors in cellular homeostasis
  • 批准号:
    RGPIN-2020-05104
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.33万
  • 财政年份:
    2020
  • 负责人:
    Stochaj, Ursula
  • 依托单位:
Novel functions of importin-alpha in RNA metabolism and the stress response
  • 批准号:
    RGPIN-2015-04137
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.77万
  • 财政年份:
    2019
  • 负责人:
    Stochaj, Ursula
  • 依托单位:
国内基金
海外基金
数学物理中精确可解模型的代数方法
  • 批准号:
    11771015
  • 项目类别:
    面上项目
  • 资助金额:
    48.0万元
  • 批准年份:
    2017
  • 负责人:
    Oleksiy Zhedanov
  • 依托单位: