Novel functions of importin-alpha in RNA metabolism and the stress response
Novel functions of importin-alpha in RNA metabolism and the stress response
批准号:
RGPIN-2015-04137
负责人:
Stochaj, Ursula
金额:
$2.77万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-12-31
中文摘要
在真核细胞中,importin-a蛋白家族(这里称为importin-a)对细胞生理学的多个方面都有贡献。除了核运输,家庭成员还参与其他重要的生物过程。近年来的研究表明,进口蛋白a在RNA代谢和应激反应中具有新的功能。因此,我们证明了importin-a1与poly(A)-RNA结合。我们还发现,进口蛋白a家族的多个成员与细胞质应激颗粒(SGs)有关。进口蛋白a是如何参与这些关键的细胞活动的还不清楚。我们的研究计划将解决这些核心的生物学问题。
英文摘要
In eukaryotic cells, the importin-a protein family (here referred to as importin-a) contributes to multiple aspects of cell physiology. Aside from nuclear transport, family members are implicated in additional vital biological processes. Recent studies suggest that importin-a has new functions in RNA metabolism and the stress response. Thus, we demonstrated that importin-a1 binds poly(A)-RNA. We also showed that multiple members of the importin-a family associate with cytoplasmic stress granules (SGs). How importin-a proteins contribute to these crucial cellular activities is not well understood. Our research program will address these central biological questions.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Novel functions of nuclear transport factors in cellular homeostasis
-
批准号:RGPIN-2020-05104
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.33万
-
财政年份:2022
-
负责人:Stochaj, Ursula
-
依托单位:
Novel functions of nuclear transport factors in cellular homeostasis
-
批准号:RGPIN-2020-05104
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.33万
-
财政年份:2021
-
负责人:Stochaj, Ursula
-
依托单位:
Novel functions of nuclear transport factors in cellular homeostasis
-
批准号:RGPIN-2020-05104
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.33万
-
财政年份:2020
-
负责人:Stochaj, Ursula
-
依托单位:
Novel functions of importin-alpha in RNA metabolism and the stress response
-
批准号:RGPIN-2015-04137
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.77万
-
财政年份:2019
-
负责人:Stochaj, Ursula
-
依托单位:
Novel functions of importin-alpha in RNA metabolism and the stress response
-
批准号:RGPIN-2015-04137
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.77万
-
财政年份:2018
-
负责人:Stochaj, Ursula
-
依托单位:
Novel functions of importin-alpha in RNA metabolism and the stress response
-
批准号:RGPIN-2015-04137
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.77万
-
财政年份:2016
-
负责人:Stochaj, Ursula
-
依托单位:
Novel functions of importin-alpha in RNA metabolism and the stress response
-
批准号:RGPIN-2015-04137
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.77万
-
财政年份:2015
-
负责人:Stochaj, Ursula
-
依托单位:
Role of importin-alpha in the regulation of glucose-responsive gene expression
-
批准号:155509-2009
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.35万
-
财政年份:2013
-
负责人:Stochaj, Ursula
-
依托单位:
Role of importin-alpha in the regulation of glucose-responsive gene expression
-
批准号:155509-2009
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.35万
-
财政年份:2012
-
负责人:Stochaj, Ursula
-
依托单位:
Role of importin-alpha in the regulation of glucose-responsive gene expression
-
批准号:155509-2009
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.35万
-
财政年份:2011
-
负责人:Stochaj, Ursula
-
依托单位:
Role of importin-alpha in the regulation of glucose-responsive gene expression
-
批准号:155509-2009
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.35万
-
财政年份:2010
-
负责人:Stochaj, Ursula
-
依托单位:
Role of importin-alpha in the regulation of glucose-responsive gene expression
-
批准号:155509-2009
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.35万
-
财政年份:2009
-
负责人:Stochaj, Ursula
-
依托单位:
Role of importin-alpha in the regulation of glucose-responsive gene expression
-
批准号:155509-2007
-
项目类别:Discovery Grants Program - Group
-
资助金额:$1.82万
-
财政年份:2008
-
负责人:Stochaj, Ursula
-
依托单位:
Role of importin-alpha in the regulation of glucose-responsive gene expression
-
批准号:155509-2007
-
项目类别:Discovery Grants Program - Group
-
资助金额:$1.82万
-
财政年份:2007
-
负责人:Stochaj, Ursula
-
依托单位:
Functional analysis of nucleoporins
-
批准号:155509-2000
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.26万
-
财政年份:2003
-
负责人:Stochaj, Ursula
-
依托单位:
Functional analysis of nucleoporins
-
批准号:155509-2000
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.26万
-
财政年份:2002
-
负责人:Stochaj, Ursula
-
依托单位:
Functional analysis of nucleoporins
-
批准号:155509-2000
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.26万
-
财政年份:2001
-
负责人:Stochaj, Ursula
-
依托单位:
Functional analysis of nucleoporins
-
批准号:155509-2000
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.26万
-
财政年份:2000
-
负责人:Stochaj, Ursula
-
依托单位:
Protein traffic in growing mammalian cells
-
批准号:155509-1996
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.27万
-
财政年份:1999
-
负责人:Stochaj, Ursula
-
依托单位:
Protein traffic in growing mammalian cells
-
批准号:155509-1996
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.16万
-
财政年份:1998
-
负责人:Stochaj, Ursula
-
依托单位:
国内基金
海外基金
数学物理中精确可解模型的代数方法
-
批准号:11771015
-
项目类别:面上项目
-
资助金额:48.0万元
-
批准年份:2017
-
负责人:Oleksiy Zhedanov
-
依托单位: