Dynamic Regulation of the Cell Surface Proteome

每个活着的细胞必须通过其外表面上的分子与周围环境相互作用。蛋白质是存在于每个细胞表面的一种重要的分子。这些细胞表面蛋白对许多细胞功能是必不可少的，包括从细胞周围吸收糖和维生素等营养物质，附着到其他细胞或组织，以及感知来自其他细胞或生物体的信息(例如通过激素)。在细胞表面发现的蛋白质是细胞过程的一部分，这可能需要细胞的大量能量资源，例如在细胞移动或迁移过程中。就像家庭的收入和支出应该平衡一样，细胞的能量消耗过程必须得到严格控制，以使能量消耗与细胞的需求和能力保持一致。

Each living cell must interact with its surroundings through the molecules present on its outer surface. Proteins are an important type of molecule found on every cell’s surface. These cell surface proteins are essential for many cellular functions including the uptake of nutrients such as sugar and vitamins from a cell's surroundings, for attachment to other cells or tissues and for sensing messages from other cells or organisms (e.g. through hormones). The proteins found on a cell’s surface work as part of cellular processes that can require a lot of a cell’s energy resources, for example in cell movement or migration. Much like household income and expenditures should be balanced, a cell’s energetically demanding processes have to be tightly controlled so that energy expenditure is kept in line with a cell’s needs and abilities.