Emerging roles of renal intercalated cells

肾脏是一个复杂的器官，因为它的不同管段的“串联”组织。收集管穿过肾皮质(皮质收集管)，然后穿过髓质(外髓和内髓)，然后在肾盆中释放最终的尿液。它至少由三种不同的细胞类型组成：主细胞(PC)、A型和B型插入细胞(IC)。尽管教科书目前将主细胞描述为调节钠和水的重吸收，而IC则负责酸碱平衡，但最近

The kidney is a complex organ due to the “in series” organization of its various tubular segments. The collecting duct runs through the renal cortex (cortical collecting duct) and then the medulla (outer and inner medulla) prior to releasing final urine in the renal pelvis. It is composed of at least three different cell types: principal cells (PC), type-A and type-B intercalated cells (IC). While textbooks currently describe principal cells as mediating sodium and water reabsorption, and IC as responsible for acid-base homeostasis, recent