Regulation of Drug Transport Proteins and Drug Metabolizing Enzymes by Nuclear Receptors

-细胞内化学分子的浓度决定了它们的活性和毒性。这不仅适用于药物，也适用于维生素和激素等内源性分子。膜转运蛋白作为一个门户，以确定可用的浓度作用于细胞内的目标。细胞内酶介导许多分子的代谢，使它们解毒和/或使它们更适合被清除。被称为核受体的蛋白质严格调节着这些转运体和代谢酶的数量。这项研究计划的总体目标是进一步了解决定药物转运体和代谢酶活性的过程。这将帮助我们了解身体处理药物、维生素和其他激素的方式。

- The intracellular concentration of chemical molecules determines their activity and toxicity. This applies not only to drugs but also to endogenous molecules such as vitamins and hormones. Membrane transport proteins act as a gateway to determine the concentration available to act on intracellular targets. Intracellular enzymes mediate the metabolism of numerous molecules to detoxify them and/or render them more suitable for elimination. Proteins called nuclear receptors tightly regulate the amount of these transporters and metabolic enzymes. The overall goal of this research program is to further our understanding of the processes that determine the activity of drug transporters and metabolic enzymes. This will help us understand the way the body handles drugs, vitamins and other hormones.