Microbial regulation of DNA repair in intestinal epithelial cells

肠道含有大量的微生物和肠上皮细胞（IEC），它们对于调节这些微生物与宿主的相互作用至关重要。IEC表达许多模式识别受体（PRR），使它们能够感知和响应微生物。这是至关重要的，因为微生物可以产生破坏DNA的产物，IEC非常容易积累突变，因为它们经常分裂，每次都必须复制它们的DNA。虽然IEC内有许多保护性DNA修复途径，但这些修复机制如何受肠道微生物产物调节的基本问题仍然没有答案，尽管这些调节途径的存在可能对基本肠道生理学产生重要影响。

The intestine contains an abundant colony of microorganisms and intestinal epithelial cells (IEC) that are critical for regulating the interaction of these microbes with the host. IEC express numerous pattern recognition receptors (PRR) that allow them to sense and respond to microbes. This is critical since microbes can produce products that damage DNA and IEC are very susceptible to accumulating mutations because they divide frequently and must reproduce their DNA each time. While numerous protective DNA repair pathways operate within IEC, the basic question of how these repair mechanisms are regulated by intestinal microbial products remains unanswered despite the fact that the existence of such regulatory pathways could have important consequences for fundamental intestinal physiology.