Investigating the role of Reep5 in formation, maintenance, and function of the endoplasmic reticulum

内质网（Endoplasmic Reticulum，ER）是真核生物中一种动态的多功能细胞器。它是一个专门的器官，负责许多功能，包括Ca2+循环，蛋白质翻译和运输。介导ER形成和维持的一组重要蛋白质是具有网状蛋白同源结构域（RHD）的蛋白质。一组RHD蛋白是受体表达增强蛋白（REEP）。REEPs在ER形成、维持和对ER应激的反应中的确切作用尚不清楚。我们正在进行的蛋白质组学研究已经确定REEP 5是一种进化保守的、富含心脏细胞的膜蛋白，是心脏中占主导地位的REEP。

The Endoplasmic Reticulum (ER) is a dynamic multi-functional organelle found in eukaryotes. It is a specialized organ responsible for many functions, including Ca2+ cycling, protein translation and trafficking. An important group of proteins that mediate formation and maintenance of the ER are proteins with ‘reticulon homology domains (RHD). One group of RHD proteins are the receptor expression-enhancing proteins (REEPs). The precise role of REEPs in ER formation, maintenance, and responses to ER stress is not well understood. Our ongoing proteomic studies have identified REEP5 to be an evolutionary-conserved, cardiac cell-enriched, membrane protein that is the dominant REEP in the heart.