Epigenetic Regulation of Adult Hippocampal Neurogenesis

了解成人大脑具有在一生中产生新神经元的先天能力，将成人神经发生的研究推向了科学研究的前沿。虽然许多因素，如衰老和运动，已被确定为调控成年海马神经发生，但目前我们对细胞自主调节海马神经前体发育从而促进海马神经发生的分子机制尚缺乏了解。由于表观遗传学已经成为整合外部信号以确定内在基因表达的分子界面，我们的长期目标是了解表观遗传学机制是如何细胞自主地调控成年海马神经发生的。基于我们最近关于组蛋白乙酰转移酶CBP(CREB结合蛋白)在调节神经干细胞生物学中的作用的卓有成效的研究，我们

Knowing the adult human brain has the innate ability to produce new neurons throughout life has propelled the study of adult neurogenesis to the forefront of scientific research. While numerous factors, such as aging and exercise, have been identified to regulate adult hippocampal neurogenesis, there is currently a gap in our knowledge with respect to the molecular mechanisms that cell-autonomously modulate hippocampal neural precursor development to contribute to hippocampal neurogenesis. Since epigenetics has emerged as a molecular interface that integrates extrinsic signals to determine intrinsic gene expressions, our long term goal is to understand how epigenetic mechanisms cell-autonomously regulate adult hippocampal neurogenesis. On the basis of our recent fruitful research regarding the role of a histone acetyltransferase, CBP (CREB binding protein) in regulating neural stem cell biology, we