Coxsackie and adenovirus receptor (CAR): a multifunctional cell adhesion molecule

科萨基和腺病毒受体（CAR）是粘附分子的免疫球蛋白超家族的成员。顾名思义，它首先被鉴定为5型腺病毒的高亲和力受体，5型腺病毒是最常用的基因转移腺病毒载体。我的实验室对CAR的兴趣源于这样一个事实，即我们通常使用腺病毒（Ad）载体将基因转移到肌肉，神经系统和肿瘤细胞。因此，我们一直对确定CAR的表达模式和调节其表达的方法感兴趣。在这个过程中，我们已经开始研究CAR在这些组织中的多种功能。

The Coxsackie and adenovirus receptor (CAR) is a member of the immunoglobulin superfamily of adhesion molecules. As its name implies, it was first identified as the high affinity receptor for adenovirus type 5, the most commonly used adenoviral vector for gene transfer. My laboratory's interest in CAR stems from the fact that we routinely use adenovirus (Ad) vectors for gene transfer to muscle, nervous system and tumour cells. As such we have been interested in determining the expression pattern of CAR and means of modulating its expression. In the process, we have started studying the multiple functions of CAR in these tissues.