Anthelmintic drug targets in the nematode neuromusculature

肌肉协调是所有动物的一个定义特征，毒素的目标是诱导瘫痪和死亡。协调是通过神经递质信号传导来维持的，由调节膜电压梯度的细胞表面受体介导。这些五聚体离子通道受体在所有动物中高度保守，并且对动物生物学的研究至关重要。寄生蠕虫对人类健康和生产力的影响仅次于疟疾，是农业的一个重大财政和管理问题。药物是我们控制这些寄生虫的唯一有效手段，但抗药性的上升需要新的药物和技术来扩大我们现有药物的效用。大多数驱虫药激活五聚体离子通道，导致瘫痪，

Muscle coordination is a defining feature of all animals, targeted by toxins to induce paralysis and death. Coordination is maintained by neurotransmitter signalling, mediated by cell surface receptors that regulate the membrane voltage gradient. These pentameric ion-channel receptors are highly conserved in all animals and are fundamentally important to the study of animal biology. Parasitic helminths are second only to malaria for their impact on human health and productivity and are a major financial and management problem for agriculture. Drugs are the only effective means we have to control these parasites but the rise of resistance requires new drugs as well as techniques to extend the utility of drugs we have now. Most anthelmintics activate pentameric ion-channels, causing paralysis so