Protein-Protein Interactions Involved in Siderophore Biosynthesis and Secretion

大多数维持生命的代谢过程都需要蛋白质之间的相互作用。此外，参与这些过程的代谢酶通常聚集成称为代谢物的大型复合物。将酶组织成代谢物可以提高代谢过程的效率，并有助于膜定位。我的实验室研究蛋白质-蛋白质相互作用在铁载体介导的细菌铁摄取中的作用。铁载体是细菌合成和分泌的小分子铁螯合剂，用于从细胞外环境中获取稀缺的铁。目前对参与铁载体生物合成的酶是如何在细菌细胞内组织的知之甚少。我们现在有证据表明参与生物合成的酶

Most metabolic processes that support life require protein-protein interactions. Furthermore, metabolic enzymes that participate in such processes are often clustered into large complexes known as metabolons. Organization of enzymes into metabolons can enhance the efficiency of metabolic processes and can facilitate membrane localization. My laboratory studies the role of protein-protein interactions in siderophore-mediated bacterial iron uptake. Siderophores are small-molecule iron chelators that bacteria synthesize and secrete to obtain scarce iron from extracellular environment. Little is currently known about how the enzymes involved in siderophore biosynthesis are organized within a bacterial cell. We now have evidence that the enzymes involved in the biosynthesis of the