Mechanistic studies of a new family of bacterial RNA chaperones

小的非编码RNA（sRNA）调节基本上所有细菌物种中的基因表达。我的实验室表明，细菌质粒的F家族中的基因表达调控是由一种称为FinO的RNA伴侣控制的，它促进了反义RNA与其mRNA靶点的相互作用。在与Xavier Charpentier（里昂）的一项新合作中，我们现在已经证明FinO样分子伴侣存在于各种细菌物种中，它们控制着不同的调控过程。Charpentier最近使用基因组方法鉴定了一对调节DNA转导的sRNA-mRNA对，

Small non-coding RNAs (sRNAs) regulate gene expression in essentially all bacterial species. My laboratory showed that the regulation of gene expression in the F family of bacterial plasmids is controlled by an RNA chaperone, called FinO, that facilitates the interactions of antisense RNAs with their mRNA targets. In a new collaboration with Xavier Charpentier (Lyons), we have now shown that FinO-like chaperones exist in a variety of bacterial species where they control diverse regulatory processes. Charpentier has recently used genomic approaches to identify an sRNA-mRNA pair that regulates DNA transduction in