Characterizing gene regulatory networks that control gut-associated immunity

我们分析了来自各种动物门的基因组序列中的免疫多样性，发现不同的生物体已经进化出了广泛的免疫控制问题的解决方案。这些不同的免疫系统与共享的基因调节电路结构相互作用。表征这些快速发展的识别和效应系统与更保守的核心发育基因调控网络的整合，以及两者之间维持免疫稳态的功能反馈是我们实验室的重点。

We have analyzed immune diversity in genome sequences from a variety of animal phyla and find that different organisms have evolved a wide range of solutions to the problem of immune control. These diverse immune systems interface with shared gene regulatory circuitry structure. Characterizing the integration of these rapidly evolving recognition and effector systems with the more conserved core developmental gene regulatory networks, and the functional feedback between the two that maintains immune homeostasis is the focus of our laboratory.