Function of ileal lipid binding proteins

脂肪酸结合蛋白(FABP)是一种广泛存在于各种组织中的小分子可溶性蛋白质。到目前为止，FABP家族有9个成员结合了小的疏水化合物。每个FABP都有不同的配基特异性，并与某些组织相关。FABP具有相似的三维结构，尽管一级结构有很大的不同，这可能是它们特有的配体偏好的原因。功能缺失突变使人们对FABP在多种代谢过程中的功能有了重要的了解，但FABP的确切分子功能仍未得到很好的理解。这些蛋白质可以作为细胞储存库，它们各自配体的胞内转运体，并作为膜结合的转运体和与基因启动子结合的同源核受体之间的穿梭。

Fatty acid binding proteins (FABPs) are abundant, small molecular weight soluble proteins found in various tissues. To date, the FABP family has 9 members that bind small hydrophobic compounds. Each FABP has a distinct ligand specificity and is associated with certain tissues. FABPs have similar three dimensional structures despite significant dissimilarity in primary structures which likely contributes to their characteristic ligand preferences. Loss-of-function mutations gave important insights into FABP function in a variety of metabolic processes, but the precise molecular functions of FABPs are still not well understood. These proteins may act as cellular storage depots, intracellular transporters for their respective ligands, and serve as intracellular shuttles between the membrane-bound transporter that internalize their ligands and the cognate nuclear receptors bound to gene promoters.