课题基金 / 基金详情

"Towards ideal opioid analgesics: Improving tolerability with novel, functionally selective MOR agonists".

"Towards ideal opioid analgesics: Improving tolerability with novel, functionally selective MOR agonists".
“迈向理想的阿片类镇痛药：通过新型功能选择性 MOR 激动剂提高耐受性”。
批准号：
370227
负责人：
Pineyro Graciela
金额：
$67.71万
依托单位：
Centre hospitalier universitaire Sainte-Justine (Montral, Qubec)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-09-01 至 2022-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=370227&lang=en
关键词：
Analgesia Chronic Pain Gpcrs Opioid Receptors Opioids Quantitative Pharmacology Signaling Bias

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中文摘要
翻译
阿片类药物是已知的最有效的止痛药，也是治疗剧烈疼痛的可选药物。然而，它们也会产生严重的副作用，限制了它们的临床应用。止痛和不良动作都来自阿片类药物结合时产生的信号
英文摘要
Opioids are the most effective analgesics known and elective in the treatment of severe pain. However, they also produce severe side effects that limit their clinical use. Analgesia and undesired actions both arise from signals produced when opioids bind
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会议论文
Harnessing in vitro signaling diversity of opioid analgesics as a means of predicting in vivo development of tolerance
12 th Annual Meeting GPCR Retreat
Functional selectivity at the post-endocytic sorting of heptahelical receptors: focus on delta opioid receptor (DOR) recycling.
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