Gut chemosensing and the regulation of nutrient absorption and barrier function in pigs

畜牧业是养殖和饲养家畜的农业实践，是世界范围内的主要粮食生产行业。这些动物的发育和生长不良、疾病、发病率和死亡率通常是由肠道健康不良引起的，与肠道渗漏、肠道萎缩、感染和炎症有关，特别是在动物年幼的时候。需要更好的解决方案，以改善肠道健康，以实现可持续的动物生产，特别是在饲料中抗生素的使用因公众日益关注而变得更加有限的情况下。肠道不仅是一个消化器官，也是一个化学感觉系统，通过肠道内以及肠道、大脑和其他器官之间的细胞和分子信号级联，协调维持动物体内平衡所需的生理和代谢反应。味觉受体包括钙感受器受体(CaSR)，在动物的各种组织中都有表达，在营养感知和调节动物的生理、生长发育等方面发挥着重要的作用。

Animal husbandry is the agricultural practice of breeding and raising livestock, and it is a major food-producing industry worldwide. Poor development and growth, disease, morbidity and mortality of these animals are often caused by poor gut health associated with leaky gut, intestinal atrophy, infection and inflammation, particularly when the animals are young. There is a need for better solutions that can be practised to improve gut health for sustainable animal production, especially when antibiotic use in feed has been becoming more limited due to mounting public concerns. The gut is not only a digestive organ but also a chemosensory system that mediates the orchestration of physiological and metabolic responses required to maintain homeostasis in animals through cellular and molecular signaling cascades within the gut and among the gut, brain and other organs. Taste receptors including calcium sensor receptor (CaSR) are expressed in various tissues of animals, play very important roles in nutrient sensing and regulate the physiology, growth and development of the animals.