Development of New Methods for Quantitative MRI

磁共振成像（MRI）在检查人体软组织方面非常有用，并且在能力和用途方面仍在迅速发展。MRI的局限性之一是它往往不能提供精确的组织测量，而是通过比较不同区域的信号来进行相对测量。如果能够为核磁共振成像开发出快速和精确的定量组织测量方法，它可以进一步提高其提供精确信息的能力，这将对医学成像和工业用途有价值。我们的实验室专门从事通过利用MRI物理基础的每一种形式的图像对比度生成新的MRI方法。我们的长期目标是不断发展新方法，增加MRI的价值，并基于对MRI物理及其与人体组织特性的关系的理解。这项研究计划将开发新的手段进行定量MRI，重点是三种独特的定量技术。这三个领域是MRI应用的新兴领域，需要进一步发展才能成为实用工具。

Magnetic Resonance Imaging (MRI) is very useful for examining soft tissue in the body and is still rapidly evolving in capability and increasing in use. One of the limitations of MRI is it tends to not provide exact tissue measurements, instead making relative measurements by comparing the signal in different areas. If fast and exact quantitative tissue measures could be developed for MRI, it could further its ability to offer precise information which would be valuable for medical imaging and industrial uses. Our laboratory specializes in the generation of new MRI methods by exploiting the MRI physics underlying each form of image contrast. Our long term goal is the continual development of novel methods that increase the value of MRI and are based on understanding MRI physics and its relationship to human tissue properties. This research proposal will develop new means of performing quantitative MRI, focusing on three unique quantitative techniques. The three areas of interest are emerging areas of MRI application that require further evolution to become practical tools.