Identification of novel replication stress response modulators through genome-wide CRISPR/Cas9 screens.
Identification of novel replication stress response modulators through genome-wide CRISPR/Cas9 screens.
批准号:
376379
负责人:
Lemay Jean-François
金额:
$9.83万
依托单位国家:
加拿大
项目类别:
Fellowship Programs
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-11-01 至 2020-11-01
中文摘要
复杂的分子机制已经发展到防止DNA损伤的过度积累,从而保护细胞免受基因组不稳定。癌症相关基因组不稳定的一个主要来源主要发生在复制阶段
英文摘要
Sophisticated molecular mechanisms have evolved to prevent the excessive accumulation of DNA damage and thereby guard cells against genome instability. A major source of cancer-associated genome instabilty occurs notably during the replication phase (S ph
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