Predoctoral Training in Cross-disciplinary Molecular and Cellular Biology

跨学科分子和细胞生物学博士前培训

• 批准号: 10089175
• 负责人: Paul Garrity
• 金额: $ 29.26万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10089175
• 关键词: Molecular and Cellular Biology; Training; pre-doctoral

Project Summary/Abstract The goals of this training program entitled “Predoctoral Training in Cross-disciplinary Molecular and Cellular Biology” (CMCB) at Brandeis University are to produce rigorous, quantitative scientists with expertise in multiple disciplines, to provide trainees with the skills needed to succeed in diverse science-related careers, and to help trainees explore and pursue their career interests in an informed manner. This new program combines the complementary strengths of two prior Brandeis T32 programs: “Genetic and Biochemical Mechanisms of Regulation, T32GM007122”, expiring after >40 years of NIGMS support, and “Quantitative Biology, T32EB009419”, expiring after 10 years of NIBIB support. While both training programs had strong track records of student research productivity and career outcomes, we significantly rethought and revised core elements of training (based on student and faculty feedback) to better prepare students for a future in which interdisciplinary research is increasingly crucial. Innovations include: (1) increased quantitative training, through courses and an annual workshop, (2) revising the timing and goal of the qualifying exam, both to improve the training value and to better serve students from diverse scientific and personal backgrounds, (3) earlier implementation of Individual Development Plans and Thesis Committee Meetings to accelerate trainee career development and research progress, (4) introducing a secondary research advisor in a complementary discipline to facilitate interdisciplinary training, (5) a two week professional Externship in Year 4+, (6) new program self-assessment mechanisms, including semi-annual trainee feedback and the creation of an External Advisory Committee, and (7) formal training in and oversight of mentoring for all training faculty. Trainee appointments will be made at the end of Year 1, after students have completed one year of coursework, four 9- week laboratory rotations, and chosen a lab. In Year 2, trainees serve as teaching assistants for one course per semester, take a Proseminar course to help them craft their thesis research plan and defend it at their qualifying exam (end of Year 2), and to develop a career Individual Development Plan (IDP). In Year 3+, trainees take a final elective and focus on their research. They present their work at annual Departmental talks, have annual Thesis Committee Meetings focused on career planning and research progress. In Year 4+, they engage in a two-week career Externship and serve as mentors at the annual Quantitative Analysis workshop. Program outcomes and success will be measured by: (1) sustained research impact (reflected in trainee publications), (2) development of independent scientific thinking and communication (assessed through thesis proposals, annual Departmental talks and Thesis Committee Meetings), (3) active trainee engagement in their own career development (reflected in annual IDPs, discussions at Thesis Committee Meetings, and the new Externship program), and (4) trainee placement and long-term success in science-related careers. There are 29 CMCB training faculty, and 12 slots are requested (~6 trainees/year, with trainees supported in Years 2 and 3).

项目总结/摘要 这项培训计划的目标，题为“跨学科的分子和细胞的博士前培训， 布兰迪斯大学的“生物学”（CMCB）旨在培养具有多方面专业知识的严谨的定量科学家。 学科，为学员提供在各种科学相关职业中取得成功所需的技能，并帮助 学员可在知情的情况下探索和追求自己的职业兴趣。这一新方案结合了 两个先前的布兰代斯T32计划的互补优势：“遗传和生化机制， 法规，T32 GM 007122”，在NIGMS支持超过40年后到期，以及“定量生物学， T32 EB 009419”，在NIBIB支持10年后到期。虽然这两个培训项目都有很强的跟踪能力， 记录学生的研究生产力和职业成果，我们显着反思和修订核心 培训要素（基于学生和教师的反馈），以更好地为学生的未来做好准备， 跨学科研究越来越重要。创新包括：（1）增加量化培训， 通过课程和年度研讨会，（2）修改资格考试的时间和目标， 提高培训价值，更好地为来自不同科学和个人背景的学生服务，（3） 提前实施个人发展计划和论文委员会会议，以加快学员 职业发展和研究进展，（4）引入辅助研究顾问， 学科，以促进跨学科的培训，（5）为期两周的专业实习在今年4+，（6）新 计划自我评估机制，包括半年一次的学员反馈和建立外部 咨询委员会，以及（7）正式培训和监督所有培训教师的辅导。见习 预约将在今年1年底，学生完成一年的课程后，四个9- 周实验室轮换，并选择了一个实验室。在第二年，受训人员担任助教， 学期，参加专业研讨会课程，帮助他们制定论文研究计划，并在资格考试中进行答辩 考试（第二年年底），并制定职业个人发展计划（IDP）。在三年级以上，学员参加一个 最后选修课，专注于他们的研究。他们在年度部门会议上介绍他们的工作， 论文委员会会议侧重于职业规划和研究进展。在4+年，他们从事 为期两周的职业实习，并在年度定量分析研讨会上担任导师。程序 成果和成功的衡量标准是：（1）持续的研究影响（反映在受训人员的出版物中）， (2)发展独立的科学思维和交流（通过论文提案评估， 年度部门会谈和论文委员会会议），（3）积极的学员参与自己的职业生涯 发展（反映在每年的国内流离失所者，在论文委员会会议的讨论，和新的实习 计划），以及（4）实习生安置和科学相关职业的长期成功。有29个CMCB 培训教师，并要求12个名额（约6名学员/年，学员在第二年和第三年的支持）。