Synthesis of a diversified boron reagent library for drug development

卫生部门面临着许多挑战。例如，耐多药病原体的出现要求开发新的抗生素药物来保护人群。在这种情况下，有机合成起着至关重要的作用。事实上，开发新的合成方法和试剂，以创造和贬低具有生物学意义的新分子，是我们改进治疗疾病的药物的基础。因此，有必要扩大可用于支持药物开发的试剂池。一种策略是使用高价值的构建模块试剂库，可以快速创建复杂和多样化的分子。因此，Intellisyn正在寻求获得多样化的高功能化有机三氟硼酸盐和硼酸，这将大大扩大他们的试剂库。这个项目的目标是创建这样一个库，使用我们小组最近开发的试剂。这将极大地扩展fintellisyn的试剂库。通过该项目提供的化合物尚未商业化，将极大地促进其药物开发管道。因此，这将有助于他们在加拿大的竞争力和扩张。此外，该项目将有助于开发新的芳基化方法，这将在有机合成领域有用。

The health sector is facing numerous challenges. For example, the emergence of multidrug-resistant pathogensrequires the development of new antibiotic drugs to protect the population. In this context, organic synthesisplays a vital role. Indeed, the development of new synthetic methods and reagents for the creation andevaluation of new molecules of biological interest is the foundation on which we improve the drugs availableto treat illnesses. Consequently, there is a need to expand the pool of reagents available supporting drugdevelopment. One strategy is to use libraries of high-value building blocks reagents that enable rapid creationof complex and diverse molecules.Intellisyn is thus looking to acquire a diversified collection of highly-functionalized organotrifluoroborate saltsand boronic acids, which will greatly expand their reagents library. The goal of this project is to create suchlibrary, using reagents recently developed in our group. This will greatly expand the reagents library ofIntellisyn. The compounds furnished through this project are not available commercially and will greatlyfacilitate their drug development pipeline. It will consequently contribute to their competitiveness andexpansion in Canada. In addition, this project will enable the development of new arylation methods that willbe useful in the field of organic synthesis.