Investigating Proliferative Cell Nuclear Antigen (PCNA) Modification as a Source of R-loops and Genome Instability in Cancer
Investigating Proliferative Cell Nuclear Antigen (PCNA) Modification as a Source of R-loops and Genome Instability in Cancer
批准号:
386610
负责人:
Wells James P
金额:
$1.27万
依托单位国家:
加拿大
项目类别:
Studentship Programs
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-12-01 至 2018-12-01
中文摘要
癌症是由正常DNA突变引起的疾病。被称为“基因组不稳定性”的高突变率会导致癌症,并且可能有多种原因。DNA的环境或内源性损伤可损害DNA复制。这种复制强调c
英文摘要
Cancer is a disease caused by mutations in normal DNA. High rates of mutations dubbed 'Genome instability' give rise to cancer, and can occur for many reasons. Environmental or endogenous damage to DNA can impair DNA replication. This replication stress c
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