Improved powder production processes

该项目将继续开展工作，以了解工艺参数如何影响我们为生产粉末而开发的冷冻干燥生物和医学解决方案的现有技术。冷冻干燥的生物医用粉末不仅用于食品，也用于制药。我们将在这个项目中采用的技术被称为大气喷雾冷冻干燥(ASFD)，它有可能比目前的方法更快、更经济，并且可以处理比目前方法所允许的更多种类的物质。在我们之前的Engage拨款期间，我们改进了对AFSD设备的监控和过程控制。在拟议的工作中，我们将研究不同的工艺参数变化对AFSD生产的粉末属性的影响。这项工作的目的是优化工艺参数，以生产出具有所需性能的粉末。将使用业界合作伙伴感兴趣的药物配方来探索AFSD的使用，并将与传统的托盘冷冻干燥进行比较。作为拟议研究的一部分，我们将检验AFSD生产干燥材料的能力，与行业合作伙伴使用的其他方法相比，该方法具有所需的特性，但处理时间和成本更少。此外，我们希望继续提高我们对工艺参数及其控制如何影响大气喷雾冷冻干燥材料的基本特性的理解。

This project will continue work aimed at understanding how process parameters affect an existing technology developed by us for freeze-drying biological and medical solutions to produce powders. Freeze-dried bio-medical powders are used in pharmaceuticals as well as for food. The technology we will employ in this project is called atmospheric spray freeze drying (ASFD) and has the potential to be faster and more economical than current methods and to work for a wider variety of substances than allowed for by current methods. During our previous Engage grant, we improved the monitoring and process control of our AFSD equipment. In the proposed work, we will examine the effects of different process parameter variations on the attributes of the powders produced with AFSD. This work will aim towards optimization of process parameters to produce powders with given desired properties. Use of AFSD will be explored using pharmaceutical formulations of interest to the industry partner and comparison to conventional tray freeze-drying will be made. As part of the proposed research, we will examine the ability of AFSD to produce dried material with desired properties but with reduced processing time and cost compared to the other methods used by the industry partner. In addition, we wish to continue improving our understanding of how process parameters and their control affect the essential properties of atmospheric spray freeze dried material.