Development and application of a novel CRISPR-based platform for the comprehensive identification of alternative splicing events underlying cell proliferation and tumorigenesis
Development and application of a novel CRISPR-based platform for the comprehensive identification of alternative splicing events underlying cell proliferation and tumorigenesis
开发和应用基于 CRISPR 的新型平台，用于全面鉴定细胞增殖和肿瘤发生背后的选择性剪接事件
批准号：
383198
负责人：
Gonatopoulos-Pournatzis Thomas
金额：
$0.07万
依托单位：
依托单位国家：
加拿大
项目类别：
财政年份：
2018
资助国家：
加拿大
项目状态：
已结题
起止时间：
2018-02-01 至 2019-02-01
中文摘要
翻译
绝大多数人类基因都经历了一个被称为选择性剪接（as）的过程，这一过程导致单个基因产生多个mRNA和蛋白质同种异构体。新一代测序技术的最新进展表明，肿瘤表现出
英文摘要
The vast majority of human genes undergo a process known as alternative splicing (AS), which leads to the production of multiple mRNA and protein isoforms from a single gene. Recent advances in next generation sequencing have revealed that tumours exhibit
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