Tendon cell mechanotransduction

这项提议是唯一一项研究人员要求建立专门的基础设施，通过特定的细胞表面受体对人体肌腱细胞进行生物力学刺激。所要求的设备包括磁力生物反应器、兼容的细胞培养阵列板和抗体涂层的磁性微珠。这一独特的系统由基尔大学开发，最近通过一家独特的供应商(MICA生物系统公司)投入商业使用，它将允许通过细胞表面机械感受器将生理上相关的机械力传递给肌腱细胞。这项技术将在理解肌腱适应机制方面向前迈出关键的一步，然后可以应用于新运动计划的设计。

This proposal is a sole investigator request for specialized infrastructure to biomechanically stimulate human tendon cells via specific cell surface receptors. The requested equipment incorporates a magnetic force bioreactor, compatible cell culture array plates, and antibody-coated magnetic microbeads. This unique system, developed at Keele university and recently made commercially available through a unique supplier (MICA Biosystems), will allow physiologically relevant mechanical forces to be delivered to tendon cells via cell surface mechanoreceptors. This technology will enable a crucial step forward in understanding the mechanisms of tendon adaptation, which can then be applied in the design of new exercise programs.